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The numerous essential functions of the RPE encompass the movement of circulating nutrients into and removal of unusable metabolites out of the photoreceptors, maintenance of the visual cycle by reprocessing vitamin A, synthesis of elements that make up the extracellular matrix, secretion of essential growth factors, absorption of stray light for improving image clarity, and phagocytosis of shed outer photoreceptor segments (27)

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Originally developed for the treatment of type 2 diabetes under the brand name Ozempic , it was later approved by the FDA for chronic weight management in 2021 under the name Wegovy