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Azelaic acid is generally used as 20% cream twice daily for melasma, reducing the MASI by 50% after 8 weeks [41]
A similar result was obtained in a murine model of HHcy (i.e., CBS +/ mice), where CBS deficiency led to an up-regulation of CSE in the mouse heart, thus confirming the imbalance in the transsulfuration pathway under HHcy conditions
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