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MOTS-c (mitochondrial ORF of the 12S rRNA type-c) is an MDP that promotes metabolic homeostasis, in part, via AMPK 15,16 and by directly regulating adaptive nuclear gene expression following nuclear translocation 17,18

Role of other factors on TRP channels and pain In addition to the oxidative stress, several other factors play a role in the induction of CIPN with/without TRP channel activation, including glutamate receptors, neuropeptides, PKC and inflammation

[DOI] [PubMed] [Google Scholar] 80.El-Hafidi M., Franco M., Ramrez A.R., Sosa J.S., Flores J.A.P., Acosta O.L., Salgado M.C., Cardoso-Saldaa G