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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]
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In addition, these effects on hepatic receptors have been shown only in animal models expressing apoC1 at supra-physiological levels
PubMed Central, Treiman, D
