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Mater Today Commun

Due to the heterogeneity of disparate symptoms in long-COVID patients, different mechanisms have been proposed, including viral persistence or reactivation, permanent inflammation, immune dysregulation, and alteration of gut microbiota, but there is not an adequate perception of this complex condition (Fernndez-de-Las-Peas et al., 2023)

In addition, the prolonged retention of drugs in the lungs because of impaired clearance mechanisms can reduce the intended effects of the treatment and increase the risk of side effects

Nevertheless, their tendency toward instability in the bloodstream, the complexity of their production, and the potential for inducing undesired immune responses or toxicity remain significant concerns in their clinical development [89]