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Description
2.4 Ions and miRNAs 2.4.1 Calcium Ca 2+ is the most widespread intracellular messenger ( 2+ release through the TRPML1 channel, which activates TFEB by calcineurin and promotes autophagy (Medina et al., 2015)
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Stress, jet lag, shift work and other sleep disturbances make it more likely to develop heart disease and risk factors for heart disease, including obesity and diabetes
It may also result in diminished muscle mass and strength (28), hence increasing the risk of falls and associated fractures (29)
