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Dysfunction within the CNS Brain imaging studies have demonstrated an association between PDPN and structural changes in key somatosensory regions, such as the thalamus and somatosensory cortex, and altered functional connectivity within ascending pain pathways and cortical regions involved in pain processing

As with any long-term supplement, it's worth taking periodic breaks and checking in with a doctor, especially if you're also on other medication

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10.3389/fimmu.2023.1303605 [DOI] [PMC free article] [PubMed] [Google Scholar] Jin X., Ding D., Yan Y., Li H., Wang B., Ma L., et al