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Description
However, Phase 1B studies with APOE3 individuals showed that bexarotene failed to increase CNS apoE or alter A levels, likely due to poor BBB permeability [210]

[PubMed] [Google Scholar] Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, Kibira S, Matsuishi T, Tsuji A

Prevalence and evaluation of B12 deficiency in patients with autoimmune thyroid disease

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