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Description
A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer

Redox regulation via Glutaredoxin-1 and Protein S-Glutathionylation

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Some phenotypes plausibly need a slower-than-label climb: lighter bodies (higher exposure per milligram), a history of severe GLP-1 gut intolerance, a high baseline heart rate, or a lean, low-reserve build
