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Indeed, promising data have been reported using the novel agent NT157, which inhibits both IGF-1R-IRS1/2 and STAT3 signaling in tumor and stromal cells, and has potent anti-tumor effects in preclinical models of melanoma and colorectal cancer [158, 159]
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Within the lung epithelial tissue, alveolar epithelial type I (AT1) cells are the primary mediators of gas exchange, occupying most of the epithelial surface
