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Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: a 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens[J]

These are highly potent compounds used at microgram-to-milligram level doses that escalate over weeks

They can stimulate an immune response by showing antigens (foreign substances) to T cells and other immune cells