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Description
Reactive oxygen species (ROS) and free radicals generated during oxidative stress can cause oxidative damage to biomolecules such as lipids, proteins, and DNA, resulting in cellular dysfunction and tissue injury
51% in the Pd arm, with a discontinuation rate of 2 vs
In yeast, 12-hydroxyeicosatetraenoic acid (which is probably a product of GPX4 depletion in mammals) is a substrate for Atg8 (MAP1LC3 [microtubule-associated protein 1 light chain 3] in mammalian cells) lipidation required to activate autophagy [156]
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