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doi: 10.1016/j.plipres.2009.08.003

Effects of different DDE exposure paradigms on testicular steroid hormone secretion and hepatic oxidative stress in male Long-Evans rats
14 It is also known that a high intake of niacin increases HDL due to a reduction in the catabolism of apolipoprotein A1 (APOA1), the main component of these lipoproteins

Though the exact mechanism of resistance development is not known, it appears to be mediated either by a mutation in thymidine Kinase (TK) (frequent) or mutation in viral DNA polymerase (less common) [5, 6]
