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The levels of histamine secreted by mast cells from Trx1-Tg mice were significantly reduced compared with that in WT mice, and the levels of intracellular ROS suggested that Trx1 inhibits mast cell degranulation by blocking ROS production (94, 96), whereas Trx1 effectively inhibits PLC, PKC, and Ca2+ influx in the signal transmission of ROS-activated FcRI-dependent mast cells ( Figure 1C )

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