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AOD 9604 vs Semaglutide (GLP-1): They Are Not the Same Tool The rise of GLP-1 medications like semaglutide has reshaped how Miami patients approach medically supervised weight management

This small molecule peptide functions as a selective nicotinamide N-methyltransferase (NNMT) inhibitor, targeting cellular metabolism at its source

Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

The compound requires subcutaneous administration for maximum bioavailability, as oral administration results in poor absorption due to first-pass metabolism