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Description
In VRK2-high tumors, VRK2 promotes SLC7A11 trafficking from the ER to the Golgi, enhancing GSH synthesis and conferring resistance to GSH inhibition
Glutaredoxin (Grx), a GSH-dependent disulfide oxidoreductase, catalyzes dithiol reactions, reducing GSH-protein mixed disulfides in a coupled system with GR and NADPH as an electron donor (58, 72)
Jin G, Lim B
T., Lindbck J., Held C., White H
