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Genetic ablation of CD38 protects against western diet-induced exercise intolerance and metabolic inflexibility

Survodutide, with its dual agonism, might offer additional benefits through increased energy expenditure and direct metabolic improvements, making the Cagrilintide vs Survodutide decision a strategic one based on desired mechanistic insights

Summary: Cagrilintide and retatrutide are investigational injectable medicines being studied for obesity and type 2 diabetes in men, targeting multiple hormonal pathways to reduce appetite, improve blood glucose control, and increase energy expenditure, but neither is currently licensed in the UK