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No formal MHRA or NICE guidance exists on combining these agents
A dysregulation of brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimers disease [2] through interference with the amyloidogenic A pathway [3], impairment of cerebral blood flow [4], and other mechanisms [5]
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These compounds penetrate the BBB in sufficient quantity to facilitate memory consolidation and retrieval in aged rats, and the scopolamine-induced amnesic rat model of AD, as measured employing the Morris water maze task of spatial memory [93]
