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Furthermore, NLRX1 overexpression enhances mitochondria-derived reactive oxygen species (ROS) generation in response to cisplatin exposure, resulting in excessive autophagy activation (Yin et al., 2018)

This recent preclinical study showed that the metabolism of racemic ketamine to (2 R ,6 R )-HNK is necessary for the antidepressant effects of ketamine, and that this metabolite itself shows antidepressant-like effects in mice that seem to be independent of the NMDAR

In contrast, the pesticide content of drinking water is regulated by the Drinking Water Directive (EU) 2020/2184, which allows a maximum pesticide content up to a limit of 0.1 g/L 6