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In preclinical studies, carotene tended to maintain myocardial GSH levels and GPX activities and reduce oxidative stress in vitro and in vivo [143, 144]
APE1 overexpression alleviates this effect, whereas its inhibition correlates with poor outcomes, suggesting a potential therapeutic target to modulate DC ferroptosis [87]

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MnSOD in oxidative stress response-potential regulation via mitochondrial protein influx
