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Compared with the OC group, the liver TG level, total liver TC level and liver weight of the mice in the Lira intervention group were significantly reduced

Collectively, these metabolomic findings confirm and extend the transcriptomic data, highlighting the role of MLKL in regulating mitochondrial function, lipid metabolism, and inflammation in visWAT under HFD conditions

By preventing highfat dietmediated changes to the levels of important proteins involved in lipid homeostasis, including fatty acid synthase (FAS), AMPactivated protein kinase (AMPK), and sirtuin1 (SIRT1), walnut supplementation reduced the accumulation of fat

2180-LB: Bimagrumab augments metabolic rate to improve incretin-induced weight loss in obese mice