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doi: 10.1016/j.freeradbiomed.2018.04.578 26 LuY.LiangX.-P.JinM.SunP.MaH.-N.YuanY.et al

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective

Plexiform Neurofibromas

The negative correlations between C4A and C4B, as well as between C4L and C4S copy numbers, more likely indicate that these loci reside at opposing ends of a risk (C4A and C4L) and protective (C4B and C4S) spectrum, existing in a state of linkage disequilibrium (143)
