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Loss-of-function mutations in human KEAP1 have been found in carcinomas of the lung (6973), gallbladder (74), ovary (75), breast (76,77), liver (73) and stomach (73)
7 Although the role of folic acid supplementation in reducing homocysteine levels as a method for preventing coronary artery disease and stroke continues to be a subject of great interest, there has been little emphasis on the potential role of vitamin B 12 deficiency as a contributing factor in the development of cardiovascular disease
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