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Evidence of its weight-lowering efficacy was accrued in the dedicated SCALE (Satiety and Clinical Adiposity Liraglutide Evidence) program
Different from the original expectation, the modification of roGFP2 did thus not result in a linear additive effect in which the resulting roGFP2-iL was expected to be slightly more negative than roGFP1-iL
This may be attributed to the ability of KD to alter metabolic pathways through inducing ketosis instead of glucose utilization (McGaugh & Barthel, 2022)
