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Additionally, dihydrofolate reductase (DHFR) is required for the regeneration of BH4 from its oxidized form, dihydrobiopterin (BH2)
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[4] [6] The direct delivery of ascorbic acid into the bloodstream allows for supraphysiological concentrations, which could have distinct biological effects, such as pro-oxidant activity in the presence of transition metals or selective cytotoxicity against certain malignant cells, although these applications remain under investigation and are not universally accepted as standard of care
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Coherently, an inverse relationship between plasma BR levels and systolic blood pressure was reported (208, 209)
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After rearranging the expression defining K a , and putting pH = -log 10 (H + ), one obtains pH = pK a + (A - ) / (HA) and further pH - pK a = log(A - ) / (HA) Then, a solution with 50% dissociation has pH equal to the pK a of the acid
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