glutathione peroxidase gsh-px คอ 4: a new player in neurodegeneration? Throughput Systems Mitochondrial Glutathione in Cellular Redox

As highlighted in Figure 1, multiple memory systems (See White, 1996, White, and associated commentaries, for an early review) are also recruited in these neurocircuits with substantial glutamatergic activity

Minoxidil is a vasodilator

Three metabolic pathways are known: - Glucuronidation (about 40% of the metabolism of the drug) - Sulfate conjugation (20-40%) - N-hydroxylation and rearrangement, then GSH conjugation (15%): the hepatic cytochrome P450 enzyme metabolizes the drug, forming a metabolite known as NAPQI (N-acetyl-p-benzo-quinone imine) that is irreversibly conjugated with sulphydryl group of glutathione

Specifically, we want to understand 1) what specifies cell identity and 2) how a cell can change its fate or state in response to intrinsic and extrinsic cues