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The safety and tolerability of Depakote ER in pediatric patients were shown to be comparable to those in adults [see Adverse Reactions (6.1, 6.2, 6.3)]

J Addict Med (2011) 5:18

In particular, during hypoxic stress, the upregulation of ACSS2 expression accelerates the uptake and utilization of acetate by cancer cells for the synthesis of acetyl-CoA