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Most of the existing research comes from rodent studies
doi: 10.1186/s41021-023-00278-1 218 WangB.QiuY.XieM.HuangP.YuY.SunQ.et al
172 Genes involved in pathways related to oxidative stress and antioxidant defense might therefore be potential genetic modifiers in AATD-related liver diseases, and warrant further investigation
This phase establishes tissue exposure to the peptide without overwhelming the signaling pathways
