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Mutations in NDDs tend to have a weaker functional impact and are more likely to influence differentiation compared to those in cancer

SNX27 recruits CFTR to the retromer complex through PDZ-based interaction The mammalian retromer complex functions as a coat complex that regulates intracellular trafficking in general by interacting with sorting nexins (SNXs), which serve as adaptor proteins that link retromer to specific cargo or membrane domains 24,26,27,28

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