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FIGURE 1 Confounding effects of dexamethasone on the ROR of fluoroquinolone-induced tendinopathy Evaluation of confounding effects of drug combinations on the ROR of tendinopathy in a population of fluoroquinolone users in FAERS, JADER, and CVARD revealed that many concomitantly used drugs affected the ROR of fluoroquinolone-induced tendinopathy (Figures 2AC and Supplementary Data S2)

Instead of viewing the glutamate/GABAglutamine cycle as individual biochemical processes, a more holistic and integrative approach is needed to advance our understanding of how neurotransmitter recycling modulates brain function in both health and disease