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Collectively, multifunctional metabolic enzymes act as pivotal hubs linking metabolic reprogramming to therapeutic resistance, serving as upstream initiators of signaling cascades that drive drug tolerance in CRC

Specifically, xCT expression levels are low in normal breast tissue samples but increased in hyperplastic breast tissue samples and across all subtypes of breast cancer (43,44)

Reduced Oxidative Damage in ALS by High-Dose Enteral Melatonin Treatment

Luteolin has also been investigated for managing post-COVID cognitive impairment in a study from Italy (NCT05311852), where its combination with PEA was associated with potential improvements in frontal lobe function and GABAergic transmission, though the trial was terminated early