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Description
The pK a of Tyr9 is 8.1 in the free GST A1-1, but the value increases to 9.2 when glutathione is bound ( a appears dependent on the ionized thiolate, since S-methylglutathione is without effect on the ionization of Tyr9
How does acetylcysteine help in paracetamol poisoning
The currently accepted explanation for this is the presence of 3 phosphatase and tensin homolog (PTEN) and 5 SH2-containing inositol phosphatase (SHIP)
Regulation of the protein disulfide proteome by mitochondria in mammalian cells
