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Systemic inflammation plays a crucial role in disease progression of cirrhosis and is a key driver for acute decompensation and thus the progression from compensated to decompensated cirrhosis [20]

After the samples were incubated for 20 min at 100 C, they were centrifuged to separate the supernatant from debris and other solid contents, and the pellet was discarded

A study in adults aged 70 and older showed increased heteroplasmy linked to an increased depression score.[ref] Rare mitochondrial mutations that cause mitochondrial diseases are also linked to major depressive disorder.[ref] In fact, one study of people with hereditary (genetic) mitochondrial diseases showed that 54% had major depressive disorder and 17% had bipolar disorder.[ref] Outside of the mitochondrial genome, genes in the nuclear genome that code for proteins in the mitochondria are also linked to depression

Though several studies have reported the efficacy of DPP-Is and GLP-1Rs in neuropathic pain animal models using sciatic nerve injury, there are very few studies that have analyzed the efficacy of these compounds in diabetic neuropathic pain animal models (Han et al., 2020)