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Clinical studies show it can lead to elevated homocysteine and methylmalonic acid levels, markers associated with increased risk of type 2 diabetes and cardiovascular diseases

Existing reviews have further highlighted that pharmacokinetic and safety characterization in humans remains incomplete, complicating clinical counseling regarding timing of discontinuation, perioperative risk stratification, and postoperative resumption (Rahman et al

Withdrawal Times: None

While small-scale studies are ongoing, the transition to adequately powered trials with comparison groups remains a research priority for advancing regulatory policy and understanding