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2012;4 doi: 10.1126/scitranslmed.3003689

The definition of free radicals is uncharged molecules (typically highly reactive and short-lived) having an unpaired valence electron. According to the Pharmacognosy Review , reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. Free radicals can be very harmful, but their production within the body is certainly not abnormal or even entirely bad

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In a turtle species in which sex is determined by temperature during egg incubation, the KDM6B H3K27me3-specific demethylase exhibits sexually dimorphic, temperature-dependent expression that regulates the sex-determining gene Dmrt1 80