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In AD, NAC elevates GSH levels to sustain GPX4 activity, thereby reducing lipid peroxidation accumulation and inhibiting key ferroptosis pathways for neuroprotection (188)
[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Fras JP, Davies MJ, Rosenstock J, et al
doi: 10.1038/nature08780 140 PatelS
However, their effectiveness requires extreme adherence, and important gaps remain, particularly in the genetic dimension
