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This might be due to the oxidation and/or degradation of glutathione over time 72 or again indicate that the effect triggered by AITC is more complex than a change in glutathione homeostasis

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The presence of the D1236 (from MRP2 substitution) instead of G1228 (wild-type MRP1) in the chimera M8 could create a steric hindrance, as shown by the Cryo-EM apo and LTC 4 bound (inward-facing) structures of bovine MRP1 40,44 (Fig