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The Significance of the Nrf2-SFN Relationship Nrf2 is ubiquitously expressed with the highest concentrations (in descending order) in the kidney, muscle, lung, heart, liver, and brain [73, 100]
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Inhibition of EphA4 expression reduces the binding of Beclin1 and p-ERK1/2, significantly reduces the formation of Beclin1-xCT complex, and decreases the expression of c-Myc, TFR1 and p-ERK1/2, thereby largely preventing the ferroptosis of spinal dorsal horn neurons induced by SCIRI
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