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While derivatization techniques significantly improve the sensitivity and accuracy of carnitine detection, they are not without drawbacks, such as the potential for incomplete reactions, additional synthetic steps prior to separation, and the challenge of separating derived from original analytes due to residual derivatization interference (Lipka et al., 2019)

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH), have become the leading causes of chronic liver disease worldwide, with increasing rates of cirrhosis, hepatocellular carcinoma, and cardiovascular complications

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