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The increased cost reflects the longer treatment time, medical supplies, nursing oversight, and the ability to include multiple nutrients in one session

Future trials should also measure important outcomes such as the clinical signs and symptoms of vitamin B 12 deficiency, health related-quality of life, socioeconomic effects, and report adverse events adequately, preferably in a primary care setting. Clinical practice guidelines British Columbia Medical Services Commission (MSC)

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Annual Review of Medicine, 59, 195-206