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the one or more hepatocyte growth factor mimics has or have a general structural formula R] -R 2 -R 3 -NH-(CH 2 ) n -C-NH 2 Ri is one of an N-acyl group, a substituted or unsubstituted phenyl, a norleucine group, and an amino acid selected from tyrosine, phenylalanine, aspartic acid, arginine, isoleucine, serine, histidine, glycine, cysteine, methionine, tryptophan, lysine norvaline, ornithine, and s -benzyl cysteine

There is no validated lab marker for NNMT inhibition outside research labs

Most previous studies were conducted using a very small number of patients and/or had a short follow-up [6,13,15-19]

In older adults with mild cognitive impairment, 16 weeks of 3 g/day supplementation produced measurable cognitive improvements, though benefits did not persist after discontinuation