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In general, the correlation between H1-H3 is easily identified even in the 1 H- 1 H COSY spectrum of a heteropolysaccharide
A reduction in expression of proteins like claudin-5 and Occludin involved in the formation of BBB TJs and various markers such as IL-8 and metalloproteinase 1 tissue inhibitor are related to increased BBB permeability, which have been observed in HD patients [114, 115]
doi: 10.1165/rcmb.2009-0054OC
Although chemical tools for RSSH generation have emerged, no convenient methodology for the controlled and extended release of RSSH over long time periods is currently available
