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7 Clinical note: These mechanisms are derived from preclinical models

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While the Phase 2 trial did not specifically stratify outcomes by baseline eGFR, GLP-1 receptor agonists as a class have demonstrated renoprotective effects in at-risk populations

A literature and patent review published in Pharmaceuticals (MDPI) summarizes that BPC-157 demonstrates a desirable safety profile in preclinical research, with only a few side effects reported across animal studies, and documents its broad activity across tissue injury, inflammatory and CNS-adjacent research models via VEGFR2-Akt-eNOS angiogenic pathways and nitric oxide signaling