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Despite the importance of glutamate and NMDAR for the healthy brain, overactivation of glutamate receptors leads to toxic levels of intracellular calcium, which can result in cell death [133, 134], for which the term excitotoxicity was coined [135]

Patients receiving injections more frequently than clinically indicatedsometimes through private clinics offering 'wellness' treatmentsmay accumulate excessive levels without medical justification

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