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Genetic variants can increase your need for riboflavin

12 Supplementing with folate, vitamins B6 and B12 is also shown to help lower homocysteine concentrations in patients affected by recurrent pregnancy loss (such as miscarriages) as well as MTHFR mutations

80 A means of resolving this situation is provided by studies which have shown that malabsorption of vitamin B 12 induced by metformin can be reversed by oral supplementation of vitamin B 12, even whilst metformin treatment is continued