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Figure 5 3.3 Gene expression of PBMC The log 2 fold changes of CNRQ were visualized in a heatmap ( Figure 6 ) to show the differences in gene expression between the time points (see Supplementary Table S1 for details)

The significant differences among means of treatments, for each criterion, were separated at p0.05 by LSD-multiple range test

In more advanced disease, these changes become more pronounced, with decreased free T3, elevated TSH, and more profound disruptions in hormone binding, metabolism, and clearance[85,86]

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