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Description
Of the factors that participate in the TSS pathway, cystathionine beta-synthase (CBS) and cystathionine -lyase (CSE) mediate the first two rate-limiting steps of TSS by condensing serine with homocysteine to cystathionine and then cysteine

doi: 10.1016/S0140-6736(97)06467-2 53 ClemmonsDRMosesACSommerAJacobsonWRogolADSleeviMRet al

But the symptoms you're attributing to high B12 are real, and they're worth investigating

Water retention may stack early on
