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ALDH2 genetic polymorphism: ALDH2 deficiency blocks acetaldehyde conversion, producing toxic accumulation and systemic symptoms including facial flushing and tachycardia even from small amounts of ethanol
There is ample evidence that a variety of environmental factors contribute to the dysregulation of gene expression caused by abnormal regulation of redox-sensitive transcriptional factors, noncoding RNAs, and epigenetic mechanisms
Meanwhile, teratoma formation is also a nonnegligible safety concern for iPSC transplantation
[Google Scholar] Joshi, S
