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Potent reversible as well as irreversible chemical inhibitors blocking DPP1 in the bone marrow have been synthetized, some of which are now being tested in preclinical and clinical trials (189)

Part of the challenge Jerne faced in determining the replication mechanism was he was an immunochemist and serologist so knew little about cells (Lefkovits, Waldmann, Aug 2025)
Side effects are uncommon but may include mild soreness at the injection site or temporary redness
J Mol Struct 1250:131817
