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Description
In addition, IGF-1R can also regulate cell adhesion by influencing matrix metalloproteinase (MMP) expression, which is essential in the degradation of ECM components, including gelatin and collagens, and plays a crucial role in helping single cancer cells to break away from primary tumors and blood vessels during cancer metastasis (Figure 1) [65,66]
The full cascade of benefits from optimized GH levels takes time to manifest because cellular repair and metabolic adjustments accumulate gradually
Other outcomes such as possible effects on ovulation and polycystic ovary syndrome are reported together, without establishing a comparison between study groups
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